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45 Interestingly, a study also shows that NADPH level is not changed by silencing PGD expression, which is possible that a temporally increased NADP + /NADPH ratio compensatory increased G6PD activity, thus generating NADPH
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KMT2C deficiency simultaneously enhances fatty acid biosynthesis and HRAS palmitoylation, activating the MAPK/ERK pathway and stabilizing resistance phenotypes
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