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Unlike retinoids or exfoliating acids, they do not typically cause irritation, peeling, or photosensitivity
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Poly (N-(2-hydroxypropyl) methacrylamide polymer) (pHPMA)-coated penetratin-insulin complex that has almost neutral surface charge showed enhanced mucus diffusion and insulin delivery in a diabetic rat model compared to nanoparticles whose surface charge is negative (Shan et al., 2015)
Nontransplanted diabetic mice were used as controls
Many therapies that perform exceptionally well in animals ultimately fail to deliver the same benefits in humans
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