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Topical application protocols Not everyone wants to inject
To improve SCD care, we must get better at immediately identifying issues with all novel treatments
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Bhupathiraju SN, Tobias DK, Malik VS, Pan A, Hruby A, Manson JE,
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Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA--gal staining
